No, as long as you follow the simple user instructions.
PrimeLister - Mercari Tool is a software that mimics the human behavior of a real user. It makes the listing operations in the exact way that a real human does. The difference here is that it operates many times faster than a human. However, we always limit the operation speed at an optimum level so it will stay undetectable. This characteristic makes it safe for sellers to use PrimeLister - Mercari Tool.
Additionally, you should be informed about the instructions that will protect you from violating Mercari's terms of use and getting your seller account banned.